American Journal of Food Science and Health
Articles Information
American Journal of Food Science and Health, Vol.7, No.3, Sep. 2021, Pub. Date: Jul. 28, 2021
Orange Fleshed Sweet Potato: A Depression Alleviating Functional Food
Pages: 67-74 Views: 96 Downloads: 23
[01] Jyosna Khanam, Institute of Nutrition and Food Science, University of Dhaka, Dhaka, Bangladesh.
[02] Sheikh Khalid Saifullah Sadi, Institute of Nutrition and Food Science, University of Dhaka, Dhaka, Bangladesh.
[03] Sheikh Nazrul Islam, Institute of Nutrition and Food Science, University of Dhaka, Dhaka, Bangladesh.
Oxidative stress induces depression. This article reports depression alleviation of Orange Fleshed Sweet Potato (OFSP) on experimental rat model. Depression was developed by confining the animal in physical constraint condition (restrained cages and exposing to light in night) and oral administration of 0.38 mg reserpine /kg body weight daily; reserpine at a dose of 30-50 mg/kg/day induces oxidative stress leading to depression due to depletion of monoamine. A 20 g raw OFSP was given orally daily to the animal for the 14 days consecutively. Development and alleviation of depression were assessed by behavioural test, atrophy of brain and adrenal gland, and analysis of stress biomarker. Reserpine induced a better depression than the physical constraint. In behavioural test- Tail suspension and Forced swim tests, OFSP showed a lowering of immobility time in tail suspension and increase of climbing time in forced swimming as compared to the negative control, but it was almost similar to that of the antidepressant clomipramine. OFSP also made a significant decrease of serum malonaldehyde (MDA) and an increase of superoxide dismutase (SOD) and nitric oxide (NO). This study revealed that orange fleshed sweet potato have depression alleviating potential in experimental animal model. The dietary intake of antioxidant carotene rich orange flesh sweet potato could fade out the oxidative stress, and thus the depression.
Orange Fleshed Sweet Potato, Chemophysical Depression, Depression Alleviation, Behavioural Assessment, Stress Biomarkers, Animal Model
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