American Journal of Food Science and Health
Articles Information
American Journal of Food Science and Health, Vol.7, No.3, Sep. 2021, Pub. Date: Jul. 28, 2021
Orange Fleshed Sweet Potato: A Depression Alleviating Functional Food
Pages: 67-74 Views: 857 Downloads: 153
Authors
[01] Jyosna Khanam, Institute of Nutrition and Food Science, University of Dhaka, Dhaka, Bangladesh.
[02] Sheikh Khalid Saifullah Sadi, Institute of Nutrition and Food Science, University of Dhaka, Dhaka, Bangladesh.
[03] Sheikh Nazrul Islam, Institute of Nutrition and Food Science, University of Dhaka, Dhaka, Bangladesh.
Abstract
Oxidative stress induces depression. This article reports depression alleviation of Orange Fleshed Sweet Potato (OFSP) on experimental rat model. Depression was developed by confining the animal in physical constraint condition (restrained cages and exposing to light in night) and oral administration of 0.38 mg reserpine /kg body weight daily; reserpine at a dose of 30-50 mg/kg/day induces oxidative stress leading to depression due to depletion of monoamine. A 20 g raw OFSP was given orally daily to the animal for the 14 days consecutively. Development and alleviation of depression were assessed by behavioural test, atrophy of brain and adrenal gland, and analysis of stress biomarker. Reserpine induced a better depression than the physical constraint. In behavioural test- Tail suspension and Forced swim tests, OFSP showed a lowering of immobility time in tail suspension and increase of climbing time in forced swimming as compared to the negative control, but it was almost similar to that of the antidepressant clomipramine. OFSP also made a significant decrease of serum malonaldehyde (MDA) and an increase of superoxide dismutase (SOD) and nitric oxide (NO). This study revealed that orange fleshed sweet potato have depression alleviating potential in experimental animal model. The dietary intake of antioxidant carotene rich orange flesh sweet potato could fade out the oxidative stress, and thus the depression.
Keywords
Orange Fleshed Sweet Potato, Chemophysical Depression, Depression Alleviation, Behavioural Assessment, Stress Biomarkers, Animal Model
References
[01] Black CN, Bot M, Scheffer PG, Cuijpers P, Penninx BW. Is Depression Associated with Increased Oxidative Stress? A Systematic Review and Meta-Analysis. Psychoneuroendocrinology 2015; 51: 164-75. 2015. doi: 10.1016/j.psyneuen.2014.09.025. Epub 2014; Oct 2. PMID: 25462890.
[02] Bajpai A, Verma AK, Srivastava M, Srivastava R. Oxidative stress and major depression. J Clin Diagn Res. 2014; 8 (12): CC04–CC07. doi: 10.7860/JCDR/2014/10258.5292 PMCID: PMC4316245.
[03] Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V, Squadrito F, Altavilla D, Bitto A. Oxidative stress: harms and benefits for human health. Oxid Med Cell Longev. 2017; 2017: 8416763. doi: 10.1155/2017/8416763S.
[04] Giugliano D, Ceriello A, Paolisso G. Oxidative stress and diabetic vascular complications. Diabetes care 1996; 9 (3): 257-67.
[05] Baynes JW. Role of oxidative stress in development of complications in diabetes. Diabetes 1991; 40 (4): 405-412.
[06] Valko M, Izakovic M, Mazur M, Rhodes CJ, Telser J. Role of oxygen radicals in DNA damage and cancer incidence. Mol Cell Biochem 2004; 266 (1-2): 37-56.
[07] Bahorun T, Soobrattee MA, Luximon-Ramma V, Aruoma OI. Free radicals and antioxidants in cardiovascular health and disease. Internet Journal of Medical Update 2006; 1 (2): 24-40.
[08] Singh RP, Sharad S, Kapur S. Free radicals and oxidative stress in neurodegenerative diseases: relevance of dietary antioxidants. J Indian Acad Clin Med 2004; (3): 218-25.
[09] Teixeira AM, Trevizol F, Colpo G, Garcia SC, Charão M, et al. Influence of chronic exercise on reserpine-induced oxidative stress in rats: Behavioral and antioxidant evaluations. Pharmacol Biochem Behavior 2008; 88: 465-472.
[10] Mariani E, Polidori MC, Cherubini A, Mecocci P. Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview. J Chromatogr B Analyt Technol Biomed Life Sci 2005; 15; 827 (1): 65-75. doi: 10.1016/j.jchromb.2005.04.023.Epub.
[11] Floyd RA, Hensley K. Oxidative stress in brain aging: implications for therapeutics of neurodegenerative diseases. Neurobiol Aging 2002; 23 (5): 795-807.
[12] Salim S. Oxidative stress and the central nervous system. J Pharmacol Exp Ther 2017; 360 (1): 201-205.
[13] Gandhi S, Abramov AY. Mechanism of oxidative stress in neurodegeneration. Oxidative medicine and cellular longevity 2012; 11 pp. ID 428010, doi: 10.1155/2012/428010.
[14] Wilson CB, Ebenezer PJ, Dange R, Francis J. Inflammation and oxidative stress are elevated in the brain, blood, and adrenal glands during the progression of post-traumatic stress disorder in a predator exposure animal model. PloS one 2017; 8 (10): e76146.
[15] Dhingra D, Gahalain N. Protective effect of ellagic acid against reserpine-induced orofacial dyskinesia and oxidative stress in rats. Pharmacologia 2016; 7: 16-21.
[16] Bilska A, Dubiel M, Sokołowska-Jez M, Lorenc-Koci E, Włodek L. Alpha-lipoic acid differently affects the reserpine-induced oxidative stress in the striatum and prefrontal cortex of rat brain. Neuroscience 2007; 146 (4): 1758-71.
[17] Negreş S., Zbarcea CE, Arsene A, Chiriţă C, Buzescu A, Velescu BS, Stefănescu E, Seremet O, Nicolescu F. Experimental pharmacological model for inducing and quantifying depression in mouse. Farmacia 2013; 61 (6): 1102-1116.
[18] Siraji D, Islam N, Begum N, Ferdousi S. Effect of Ocimum sanctum Linn (Tulsi) on body weight and some biochemical parameters in restraint stressed balbino rats. J Bangladesh Soc Phsysiol 2008; 3: 29-43.
[19] Rabiei, Gholami M, Rafieian-Kopaei M. Atidepressant effect Mentha pulegium in mice. Bangladesh J Pharmacol 2016; 11 (3): 711-715.
[20] Nishizawa K, Torii, K., Kawasaki, A., Katada, M., Ito, M., Terashita, K., Aiso, S. and Matsuoka, M. Antidepressant-like effect of Cordycepssinensis in the mouse tail suspension test. Biological and Pharmaceutical Bulletin 2007; 30 (9): 1758-1762.
[21] Islam SN, Nusrat T, Begum P, Ahsan M. Carotenoids and β-carotene in orange fleshed sweet potato: A possible solution to vitamin A deficiency. Food Chemistry 2016; 199, 628-631.
[22] Alam MK, Rana ZH, Islam SN. Comparison of the Proximate Composition, Total Carotenoids and Total Polyphenol Content of Nine Orange-Fleshed Sweet Potato Varieties Grown in Bangladesh. Foods 2016; 5 (3): 64. doi: 10.3390/foods5030064.
[23] Sies H, Stahl W, Sundquist AR. Antioxidant Functions of Vitamins: Vitamins E and C, Beta-Carotene, and Other Carotenoids. Ann N Y Acad Sci 1992; 669: 7-20.
[24] Sies H, Stahl W. Vitamins E and C, beta-carotene, and other carotenoids as antioxidants. Am J Clin Nutr 1995; 62 (6): 1315S-21S.
[25] Steru L, Chermat R, Thierry B, Simon P. The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacol 1985; 85 (3): 367-370.
[26] Porsolt RD, Bertin A, Jalfre M. Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther 1977; 229 (2): 327–336.
[27] Buge JA, Aust SD. The thiobarbituric acid assay. In the Microsomal lipid peroxidation. Method enzymol 1978; 52: 302-310.
[28] Magnani L, Gadou EM, Hubaud J. Spectrophotometric measurement of antioxidant properties of flavones and flavonols against superoxide anion. Analytica Chimica Acta 2000; 411: 209-216.
[29] Menaka KB, Ramesh A, Thomas B, Kumari NS. Estimation of Nitric Oxide as an Inflammatory Marker in Periodontitis. J Indian Soc Periodontol1 2009; 3 (2): 75-78.
[30] Choi MH, Ow JR, Yang ND, Taneja R. Oxidative Stress-Mediated Skeletal Muscle Degeneration: Molecules, Mechanisms, and Therapies. Oxid Med Cell Longev 2016; 2016: 6842568. doi: 10.1155/2016/6842568.
[31] Legg TJ. Fatigue and Depression: Are They Connected? 2017. https://www.healthline.com/health/depression/fatigue
[32] Grotto D, Maria LS, Valentini J, Paniz C, Solange GS, Garcia C. Importance of the lipid peroxidation biomarkers and methodological aspects for malondialdehyde quantification. Quim. Nova 2009; 32 (1): 169-174.
[33] Ulrich-Lai YM, Figueiredo HF, Ostrander MM, Choi DC, Engeland WC, Herman JP. Chronic stress induces adrenal hyperplasia and hypertrophy in a subregion specific manner. Am J Physiol Endocrinol Metab 2006; 291: E965–E973. doi: 10.1152/ajpendo.00070.2006.
[34] Neela S, Fanta SW. Review on nutritional composition of orange-fleshed sweet potato and its role in management of vitamin A deficiency. Food Sci Nutr 2019; 7: 1920-1945.
[35] Sadi SKF. Therapeutic use of neuroprotective nutraceuticals in experimental neurologic disorder. M. Phil. thesis, Institute of Nutrition and Food Science, University of Dhaka, Bangladesh, 2017.
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