[01] Oyewo Emmanuel Bukoye, Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria. [02] Adekunle Adeniran Sanmi, Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria. [03] Afolabi Olusegun Kayode, Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria. [04] Ige Peace Temidayo, Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria. [05] Akanji Musbau Adewumi, The Department of Biochemistry, Faculty of Science, Federal University of Technology, Minna, Nigeria.

Purpose: This research investigated some health implications of the daily consumption of palm wine and orijin bitters in male Wistar rats fed with atherogenic diet. Materials and Methods: One hundred and fifteen rats were allotted into two groups comprised of 65 and 50 rats, and fed with atherogenic diet (AD) or non-atherogenic diet (N) for six weeks respectively. The rats were administered palm wine and orijin bitters daily, such that: A (AD), B (AD + palm wine), C (AD + orijin bitters), D (AD + simvastatin), E (N), F (N + palm wine), G (N + orijin bitters) for twelve weeks. Results: AD reduced feed intake, which increased after alcoholic beverages were administered (p<0.05). Serum HDL-C and esterified cholesterol were increased (p<0.05) in alcoholic beverages only administered rats, while other lipid parameters were increased (p<0.05) in the AD fed rats. AD and alcoholic beverages increased (p<0.05) total cholesterol and triglycerides in the liver, small intestine and heart. Increases (p<0.05) were obtained in oxLDL-C in the heart and plasma in the AD fed rats, while paraoxonase, glutathione peroxidase and reduced glutathione were reduced (p<0.05). Malondialdehyde was increased (p<0.05) in the liver, heart, small intestine and blood. Increases (p<0.05) were recorded in prealbumin, interleukin-6, TNF-α and C-reactive protein in all the rats, and AD reduced (p<0.05) total immunoglublin and phagocytic capabilities. Conclusions: From the foregoing, it was evident that the administration of the alcoholic beverages severed the hyperlipidemic responses precipitated by the AD and down modulated the immune response. Therefore, the indulgence in alcoholic beverages is highly discouraged with AD.

Alcoholic Beverages, Atherogenic Diets, Down Modulated, Hyperlipidemic Responses, Immune Response, Inflammatory Disorders, Severed

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