Public Health and Preventive Medicine
Articles Information
Public Health and Preventive Medicine, Vol.4, No.3, Sep. 2018, Pub. Date: Jun. 14, 2018
Folic Acid Supplementation: A Review of the Known Advantages and Risks
Pages: 51-59 Views: 1755 Downloads: 511
Authors
[01] Faehaa Azher Al-Mashhadane, Department of Dental Basic Sciences, University of Mosul, Mosul, Iraq.
[02] Alyaa Azher Al-Mashhadane, Ministry of Health, Al-Salam Hospital, Mosul, Iraq.
[03] Amer Abdul Rhman Taqa, Department of Dental Basic Sciences, University of Mosul, Mosul, Iraq.
Abstract
Folate is required for metabolic processes and neural development. The aim of this paper was to review the effects of folic acid supplementation before and throughout pregnancy on fetal development, summarize research needs with a focus on studying the effects of correct dosage folic acid. Methods: Related publications were reviewed to determine and quantify associations of maternal use of folic acid before conception and during pregnancy as risk factor for Neural Tube Defects (NTD), Orofacial Clefts, ischemic heart diseases, Unmetabolised folic acid, Masking of B12 Deficiency Anemia and cancer. Evidence on maternal drug use before conception and during pregnancy as risk factor for developmental defect from epidemiological studies is still very limited. This review showed that a high prevalence of malformations and diseases that affect fetus could be related to the mother folic acid supplementation before and during pregnancy. Challenges in global prevalence estimation include quality of surveillance methods, geographic and socioeconomic factors, availability and use of folic acid, racial–ethnic and genetic factors, and limitations in education and access to care. For primary prevention of NTD in women with no prior affected pregnancy, 0.4 mg daily dose of folic acid was recommended and 4.0 mg daily dose was effective in preventing NTD in women with a prior affected pregnancy. Also Maternal supplementation in early pregnancy reduces the risk of oral cleft in infants, evidence from the literature serve to reassure women planning a pregnancy to consume folic acid during the periconception period to protect against oral clefts. Several studies have confirmed that folic acid supplementation before pregnancy was associated with a reduced risk of ischemic heart diseases, lower dietary folate intake during pregnancy was associated with increased risk. Folic acid may prevent or promote cancer development and progression depending on the timing of intervention In conclusion and based on the evidence evaluated, caution regarding under and/or over folic acid supplementation is warranted.
Keywords
Folic Acid, Pregnancy, Dose
References
[01] Soni MG, Thurmond TS, Miller ER, Spriggs T, Bendich, A and Omaye ST. Safety of Vitamins and Minerals: Controversies and Perspective. TOXICOLOGICAL SCIENCES 2010; 118 (2): 348–355.
[02] Zhao M, Chen Y. H, Chen X, Dong X. T. Folic acid supplementation during pregnancy protects against lipopolysaccharide-induced neural tube defects in mice. Toxicology Letters 2014; 224 (2): 201-208.
[03] Schmidt RJ, Tancredi DJ, Ozonoff S, Hansen RL, Hartiala J, Allayee H, Schmidt LC, Tassone F, and Hertz-Picciotto I. Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study. Am J Clin Nutr 2012; 96: 80–9.
[04] Li Z, Ye R, Zhang L, Li H, Liu J, Ren A. Periconceptional folic acid supplementation and the risk of preterm births in China: a large prospective cohort study. Int J Epidemiol 2014.
[05] Sengpiel V, Bacelis J, Myhre R, Myking S, Devold Pay A, Haugen M. Folic acid supplementation, dietary folate intake during pregnancy and risk for spontaneous preterm delivery: a prospective observational cohort study. BMC Pregnancy and Childbirth 2013; 13: 160.
[06] Veeranki SP, Gebretsadik T, Dorris SL, Mitchel EF, Hartert TV, Cooper WO, Tylavsky FA, Dupont W, Hartman TJ, Carroll KN. Association of folic Acid supplementation during pregnancy and infant bronchiolitis. Am J Epidemiol 2014; 15; 179 (8): 938-46.
[07] Jennings BA, Willis G. How folate metabolism affects colorectal cancer development and treatment; a story of heterogeneity and pleiotropy. Cancer Lett. 2014 Mar 12: S0304-3835 (14) 00131-1.
[08] Wiens D, DeSoto MC. Is High Folic Acid Intake a Risk Factor for Autism?-A Review. Brain Sci. 2017 10; 7 (11).
[09] Wehby G, Jeffrey C. Murray. Folic Acid and Orofacial Clefts: A Review of the Evidence. Oral Dis. 2010; 16 (1): 11–19.
[10] Viswanathan M, Treiman KA, Doto JK et al. Folic Acid Supplementation: An Evidence Review for the U.S. Preventive Services Task Force. AHRQ Publication 2017 No. 14-05214-EF-1.
[11] dKhan MFJ, Little J, Mossey PA, Steegers-Theunissen RP, Autelitano L, Lombardo I, Andreasi RB, Rubini M. Evaluating LINE-1 methylation in cleft lip tissues and its association with early pregnancy exposures. Epigenomics 2018 Jan; 10 (1): 105-113.
[12] Wehby G, Goco N, Moretti-Ferreira D, Felix T, Richieri-Costa A, Padovani C, Queiros F, Guimaraes CV, Pereira R, Litavecz S, Hartwell T, Chakraborty H, Javois L and Murray JC. Oral cleft prevention program (OCPP). BMC Pediatrics 2012; 12: 184.
[13] Dunlap B, Shelke K, Salem SA, Keith LG. Folic acid and human reproduction—ten important issues for clinicians. J Exp Clin Assist Reprod 2011; 8: 2.
[14] Crider KS, Bailey LB and Berry RJ. Folic Acid Food Fortification—Its History, Effect, Concerns, and Future Directions. Nutrients 2011; 3: 370-384.
[15] Tettamanti L, Avantaggiato A, Nardone M, Silvestre-Rangil J, Tagliabue A. Cleft palate only: current concepts. Oral Implantol (Rome) 2017; 10 (1): 45-52.
[16] Daly S, Mills JL, Molloy AM, Conly M, Mcpartlin J, Lee YJ, Young PB, Kirke PN, Weir DJ and Scott JM. Low-dose folic acid lowers plasma homocysteine levels in women of child-bearing age. QJ Med 2002; 95: 733–740.
[17] Tighe P, Ward M, McNulty H, Finnegan O, Dunne A, Strain JJ, Molloy AM, Duffy M, Pentieva K, and Scott JM. A dose-finding trial of the effect of long-term folic acid intervention: implications for food fortification policy. Am J Clin Nutr 2011; 93: 11–8.
[18] Bailey RL, Mills JL, Yetley EA, Gahche JJ, Pfeiffer CM, Dwyer JT, Dodd KW, Sempos CT, Betz JM, and Picciano MF. Unmetabolized serum folic acid and its relation to folic acid intake from diet and supplements in a nationally representative sample of adults aged 60 y in the United States. Am J Clin Nutr 2010; 92: 383–9.
[19] Sweeney MR, McPartlin J and Scott J. Folic acid fortification and public health: Report on threshold doses above which unmetabolised folic acid appear in serum. BMC Public Health 2007; 7: 41.
[20] Crider KS, Bailey LB and Berry RJ. Folic Acid Food Fortification—Its History, Effect, Concerns, and Future Directions. Nutrients 2011; 3: 370-384.
[21] Sie KY, Chen J, Sohn KJ, Croxford R, Thompson LU, Kim Y. Folic acid supplementation provided in utero and during lactation reduces the number of terminal end buds of the developing mammary glands in the offspring. Cancer letters 2009; 280 (1): 72-77.
[22] Baggott JE, Oster RA, Tamura T. Meta-analysis of cancer risk in folic acid supplementation trials. Cancer Epidemiology 2012; 36 (1): 78–81.
[23] Takata Y, Shrubsole MJ, Li H, Cai Q, Gao J, Wagner C, Wu J, Zheng W, Xiang YB, Shu XO. Plasma folate concentrations and colorectal cancer risk: a case-control study nested within the Shanghai Men's Health Study. Int J Cancer 2014.
[24] Kawakita D, Lee YA, Gren LH, Buys SS, La Vecchia C, Hashibe M. The impact of folate intake on the risk of head and neck cancer in the prostate, lung, colorectal, and ovarian cancer screening trial (PLCO) cohort. Br J Cancer 2017.
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