[01] Payam Hashemi, Faculty of Medicine, Tehran University of Medical Science (TUMS), Tehran, Iran. [02] Shaghayegh Pezeshki, Department of Immunology, School of Medicine, Iran University of Medical Science (IUMS), Tehran, Iran.

Cytokines play a substantial role in many biologic mechanisms of body organs. The mechanisms involved in production and receptor pathways of these important proteins are not completely understood. For more study about receptor and producing signaling of cytokines, we design a panel to investigate the mechanisms which interfere with this biologic process. For more detail explanation of our idea, we focused on IL-17 secretion from T helper 17 cells of healthy and psoriatic groups in both in vitro and in vivo panels. With operating this research panel, we would have better comprehension about mechanisms involved in releasing of IL-17 from T helper 17 cells of both healthy and psoriatic groups. We would also have better understanding around IL-17 receptor signaling pathways of both normal and psoriatic subsets. Along the way, we could realize changes of mentioned mechanisms in psoriasis which should consider as potential therapeutic targets. Moreover, this study encompassed the new onset patients of psoriasis for evaluation of mechanisms related to initiation of this disease. We concluded that this panel has the capability to be an effective method for assessment of signaling pathways of different secretory agents which release from various cells. Furthermore, this panel is capable to illustrate gene expression changes which occur in many processes such as aging, wound healing, inflammatory diseases, malignancies, etc.

Cytokines Signalling, IL-17, Gene Expression Pattern, Psoriasis, Inflammation, Speculation of IL-17 Generation Signalling

[01] Leonard WJ. Cytokines and immunodeficiency diseases. Nat Rev Immunol. 2001; 1 (3): 200–8. [02] Moudgil KD, Choubey D. Cytokines in autoimmunity: Role in induction, regulation, and treatment. J Interf Cytokine Res. 2011; 31 (10): 695–703. [03] Scanzano A, Cosentino M. Adrenergic regulation of innate immunity: A review. Front Pharmacol. 2015; 6 (Aug). [04] Wu H, Chen J, Song S, Yuan P, Liu L, Zhang Y, et al. Β2-Adrenoceptor Signaling Reduction in Dendritic Cells Is Involved in the Inflammatory Response in Adjuvant- Induced Arthritic Rats. Sci Rep [Internet]. 2016; 6 (April): 1–11. Available from: http://dx.doi.org/10.1038/srep24548 [05] Yulianti Bisri D, Wullur C, Lalenoh DC, Bisri T. Serum Interleukin-6 Level after Cyclooxygenase-2 Inhibitor Treatment in Moderate Traumatic Brain Injury. J Anesth Clin Res. 2017; 08 (03): 6–11. [06] Shea JJO, Murray PJ. The Ying and Yang of STAT3 in Human Disease Tiphanie. Immunity. 2009; 28 (4): 477–87. [07] Reszke R, Szepietowski JC. Secukinumab in the treatment of psoriasis: An update. Immunotherapy. 2017; 9 (3): 229–38. [08] Brodalumab (Rx). Medscape. 2020. p. 1000097. [09] Nakajima K, Kanda T, Takaishi M, Shiga T, Miyoshi K, Nakajima H, et al. Distinct Roles of IL-23 and IL-17 in the Development of Psoriasis-Like Lesions in a Mouse Model. J Immunol. 2011; 186 (7): 4481–9. [10] Haidula T. Windhoek Central Hospital overwhelmed. The Namibian. 2016; 2015 (11): 5. [11] Gjerstad JK, Lightman SL, Spiga F. Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility. Stress [Internet]. 2018; 21 (5): 403–16. Available from: https://doi.org/10.1080/10253890.2018.1470238 [12] C. Musolino, A. Allegra, V. Innao, A. G. Allegra, G. Pioggia, and S. Gangemi, “Inflammatory and Anti-Inflammatory Equilibrium, Proliferative and Antiproliferative Balance: The Role of Cytokines in Multiple Myeloma,” Mediators Inflamm., vol. 2017. [13] N. A. Spidale et al., “Neonatal-derived IL-17 producing dermal GD T cells are required to prevent spontaneous atopic dermatitis,” Elife, vol. 9, pp. 1–23, 2020. [14] T. Doughty and E. Kerkhoven, “Extracting novel hypotheses and findings from RNA-seq data,” FEMS Yeast Res., vol. 20, no. 2, pp. 1–7, 2020. [15] T. Kuwabara, F. Ishikawa, M. Kondo, and T. Kakiuchi, “The Role of IL-17 and Related Cytokines in Inflammatory Autoimmune Diseases,” Mediators Inflamm., vol. 2017.